32岁的程序员小陈和同龄的健身教练老李是大学室友，十年后同学聚会，两人的状态却天差地别。

小陈长期加班，凌晨2点睡是常态，黑眼圈深得像熊猫，头发稀疏，动不动就感冒。最近体检，血糖偏高，医生警告他再这样下去，糖尿病和心血管疾病风险大增。

而老李每晚10点半准时睡觉，皮肤紧致，精神饱满，体检各项指标正常。小陈不服气：“我周末补觉不就行了？”

熬夜与不熬夜的身体，究竟会有多大差别？让我们用科学数据来说话。

参考资料：

[1]Le Fur l，Reinberg A，Lopez S， et al. Analysis of circadian and ultradian rhythms of skin surface properties of face and forearm of healthy women.J Invest Dermatol 2001;117：718-24.

[2]Spiegel，Karine et al.“Brief communication： Sleep curtailment in healthy young men is associated with decreased leptin levels， elevated ghrelin levels，and increased hunger and appetite.”Annals of internal medicine vol.141，11 (2004)：846-50.doi：10.7326/0003-4819-141-11-200412070-00008

[3]Zheng，Bang et al.“Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults： A10-year cohort.”Neurology vol. 93，23 (2019)：e2110-e2120.doi：10.1212/WNL.0000000000008581

[4]Chu， Congying et al.“Total Sleep Deprivation Increases Brain Age Prediction Reversibly in Multisite Samples of Young Healthy Adults.” The Journal of neuroscience：the official journal of the Society for Neuroscience vol. 43，12 (2023)：2168-2177.doi：10.1523/JNEUROSCI.0790-22.2023

[5]Tian，Tian et al.“Joint effects of sleep disturbance and renal function impairment on incident new-onset severe metabolic dysfunction-associated steatotic liver disease.” Diabetes，obesity & metabolism vol. 26，10(2024)： 4724-4733.doi：10.1111/dom.15841